/*
 * TenuMed disease solution page, desktop.
 * Visual system: Japanese medical minimalism, 8px spacing rhythm, restrained motion.
 */
.disease-page{background:#f7fbff;color:#0b2341;overflow:hidden}
.disease-shell{width:min(1180px,calc(100% - 48px));margin:0 auto}
.disease-hero{position:relative;padding:120px 0 96px;background:linear-gradient(120deg,#f8fbff 0%,#edf7ff 52%,#fff 100%);border-bottom:1px solid #d9e8f7}
.disease-hero:before{content:"";position:absolute;inset:0;background:linear-gradient(rgba(0,102,204,.045) 1px,transparent 1px),linear-gradient(90deg,rgba(0,102,204,.045) 1px,transparent 1px);background-size:40px 40px;mask-image:linear-gradient(90deg,#000 0%,rgba(0,0,0,.55) 48%,transparent 90%)}
.disease-hero__grid{position:relative;display:grid;grid-template-columns:minmax(0,1.05fr) minmax(340px,.95fr);gap:64px;align-items:center}
.disease-eyebrow{display:flex;align-items:center;gap:12px;color:#0066cc;font-size:13px;font-weight:800;letter-spacing:.16em;text-transform:uppercase;margin-bottom:24px}
.disease-eyebrow:before{content:"";width:40px;height:1px;background:#0066cc}
.disease-hero h1{font-size:clamp(42px,5.8vw,76px);line-height:1.04;margin:0 0 24px;font-weight:900;color:#072b5f;letter-spacing:0}
.disease-lead{font-size:19px;line-height:1.85;color:#41556f;max-width:760px;margin:0 0 32px}
.disease-actions{display:flex;gap:16px;flex-wrap:wrap;margin-bottom:32px}
.disease-btn{display:inline-flex;align-items:center;justify-content:center;gap:8px;border-radius:999px;padding:16px 24px;font-weight:800;text-decoration:none;transition:transform .24s ease,box-shadow .24s ease,border-color .24s ease,background-color .24s ease,color .24s ease}
.disease-btn--primary{background:linear-gradient(135deg,#0066cc,#004f9f);color:#fff;box-shadow:0 16px 32px rgba(0,102,204,.24)}
.disease-btn--ghost{background:#fff;color:#0066cc;border:1px solid #b9d8f6}
.disease-btn:hover{transform:translateY(-2px);text-decoration:none}
.disease-btn--primary:hover{color:#fff;box-shadow:0 20px 40px rgba(0,102,204,.28)}
.disease-btn--ghost:hover{color:#0052a3;border-color:#0066cc}
.disease-metrics{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:16px;max-width:680px}
.disease-metric{background:rgba(255,255,255,.78);border:1px solid #d8e9f8;border-radius:16px;padding:16px;box-shadow:0 16px 40px rgba(5,45,90,.08)}
.disease-metric strong{display:block;font-size:20px;color:#062a58;margin-bottom:4px}
.disease-metric span{font-size:13px;color:#5b6f88}
.disease-visual{position:relative}
.disease-visual img{width:100%;height:520px;object-fit:cover;border-radius:32px;box-shadow:0 28px 72px rgba(10,45,85,.18)}
.disease-visual__note{position:absolute;left:-32px;bottom:40px;background:#fff;border:1px solid #d5e5f5;border-radius:24px;padding:24px;max-width:352px;box-shadow:0 24px 64px rgba(10,45,85,.14)}
.disease-visual__note small{display:block;color:#b18828;font-size:12px;font-weight:900;letter-spacing:.14em;margin-bottom:8px}
.disease-visual__note strong{font-size:18px;line-height:1.5;color:#08264d}
.disease-section{padding:96px 0}
.disease-section--white{background:#fff}
.disease-section__head{display:flex;justify-content:space-between;gap:32px;align-items:flex-end;margin-bottom:40px}
.disease-section__head h2{font-size:clamp(30px,4vw,48px);line-height:1.14;margin:0;color:#061f43;font-weight:900}
.disease-section__head p{max-width:520px;margin:0;color:#5b6f88;line-height:1.8}
.trend-grid{display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:24px}
.trend-card{background:#fff;border:1px solid #dce9f6;border-radius:24px;padding:32px;box-shadow:0 20px 48px rgba(8,41,83,.06);transition:transform .24s ease,box-shadow .24s ease,border-color .24s ease}
.trend-card:hover{transform:translateY(-2px);border-color:#bfdbf7;box-shadow:0 24px 56px rgba(8,41,83,.08)}
.trend-card span{display:inline-flex;width:40px;height:40px;border-radius:12px;align-items:center;justify-content:center;background:#eef6ff;color:#0066cc;font-weight:900;margin-bottom:24px}
.trend-card h3{font-size:20px;line-height:1.45;margin:0 0 16px;color:#08264d}
.trend-card p{margin:0;color:#526982;line-height:1.75}
.japan-edge{display:grid;grid-template-columns:minmax(0,.85fr) minmax(0,1.15fr);gap:24px;align-items:stretch}
.edge-panel{border-radius:32px;padding:32px;background:linear-gradient(145deg,#062852,#0057ad);color:#fff;box-shadow:0 24px 64px rgba(0,72,140,.22)}
.edge-panel h2{font-size:36px;line-height:1.18;margin:0 0 24px;color:#fff}
.edge-panel p{line-height:1.86;color:#d8eaff;margin:0}
.edge-list{display:grid;gap:16px}
.edge-item{display:grid;grid-template-columns:40px 1fr;gap:16px;background:#fff;border:1px solid #dbeafa;border-radius:24px;padding:24px}
.edge-item i{width:40px;height:40px;border-radius:16px;background:#edf7ff;color:#0066cc;display:flex;align-items:center;justify-content:center}
.edge-item h3{margin:0 0 8px;font-size:19px;color:#092b56}
.edge-item p{margin:0;color:#536b85;line-height:1.75}
.pathway{display:grid;grid-template-columns:repeat(5,minmax(0,1fr));gap:0;background:#fff;border:1px solid #d7e6f6;border-radius:24px;overflow:hidden;box-shadow:0 18px 48px rgba(10,45,85,.06)}
.path-step{position:relative;padding:32px 24px;min-height:232px}
.path-step:not(:last-child){border-right:1px solid #d7e6f6}
.path-step b{display:inline-flex;width:44px;height:44px;border-radius:50%;align-items:center;justify-content:center;background:#0066cc;color:#fff;margin-bottom:24px;box-shadow:0 12px 24px rgba(0,102,204,.22)}
.path-step h3{font-size:20px;margin:0 0 16px;color:#08264d}
.path-step p{margin:0;color:#526982;line-height:1.7}
.resource-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:24px}
.resource-card{background:#fff;border:1px solid #dbe8f5;border-radius:24px;overflow:hidden;box-shadow:0 20px 48px rgba(8,41,83,.07);transition:transform .24s ease,box-shadow .24s ease,border-color .24s ease}
.resource-card:hover{transform:translateY(-2px);border-color:#bfdbf7;box-shadow:0 24px 56px rgba(8,41,83,.1)}
.resource-card img{width:100%;height:208px;object-fit:cover}
.resource-card__body{padding:32px}
.resource-card .tag{display:inline-flex;border-radius:999px;background:#eef6ff;color:#0066cc;font-size:12px;font-weight:900;padding:8px 12px;margin-bottom:16px}
.resource-card h3{font-size:24px;line-height:1.35;margin:0 0 16px;color:#08264d}
.resource-card p{line-height:1.75;color:#526982;margin:0}
.matrix-wrap{overflow:auto;border-radius:24px;border:1px solid #d8e8f7;background:#fff;box-shadow:0 18px 48px rgba(8,41,83,.06)}
.disease-matrix{width:100%;border-collapse:collapse;min-width:760px}
.disease-matrix th{background:#08264d;color:#fff;text-align:left;padding:16px;font-size:14px}
.disease-matrix td{padding:16px;border-top:1px solid #e4edf7;color:#405973;line-height:1.65;vertical-align:top}
.disease-matrix td:first-child{font-weight:800;color:#08264d;width:18%}
.notice-box{margin-top:24px;background:#fff8ea;border:1px solid #f0d7a0;border-radius:20px;padding:24px;color:#69502a;line-height:1.8}
.cta-band{background:linear-gradient(135deg,#07264f,#005ebd);padding:72px 0;color:#fff}
.cta-band__inner{display:flex;align-items:center;justify-content:space-between;gap:32px}
.cta-band h2{font-size:38px;line-height:1.2;margin:0 0 16px;color:#fff}
.cta-band p{margin:0;color:#d8eaff;line-height:1.8}
.source-list{font-size:13px;color:#71849b;line-height:1.8;margin-top:24px}
.source-list a{color:#0066cc}
@media (max-width:1100px){
  .disease-hero__grid,.japan-edge{grid-template-columns:1fr}
  .trend-grid,.resource-grid{grid-template-columns:repeat(2,1fr)}
  .pathway{grid-template-columns:1fr}
  .path-step:not(:last-child){border-right:0;border-bottom:1px solid #d7e6f6}
  .disease-visual__note{left:24px;right:24px;bottom:24px}
  .disease-visual img{height:440px}
}
@media (max-width:720px){
  .disease-shell{width:min(100% - 32px,1180px)}
  .disease-hero{padding:72px 0 56px}
  .disease-lead{font-size:16px}
  .disease-metrics,.trend-grid,.resource-grid{grid-template-columns:1fr}
  .disease-section{padding:64px 0}
  .disease-section__head,.cta-band__inner{display:block}
  .disease-visual img{height:320px;border-radius:24px}
  .disease-visual__note{position:relative;left:auto;right:auto;bottom:auto;margin:-48px 16px 0}
  .edge-panel{padding:32px}
  .cta-band h2{font-size:30px}
  .disease-btn{width:100%}
}